3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress
SM Rothman, N Herdener, S Camandola, SJ Texel… - Neurobiology of …, 2012 - Elsevier
Chronic stress may be a risk factor for developing Alzheimer's disease (AD), but most
studies of the effects of stress in models of AD utilize acute adverse stressors of
questionable clinical relevance. The goal of this work was to determine how chronic
psychosocial stress affects behavioral and pathological outcomes in an animal model of AD,
and to elucidate underlying mechanisms. A triple-transgenic mouse model of AD (3xTgAD
mice) and nontransgenic control mice were used to test for an affect of chronic mild social …
studies of the effects of stress in models of AD utilize acute adverse stressors of
questionable clinical relevance. The goal of this work was to determine how chronic
psychosocial stress affects behavioral and pathological outcomes in an animal model of AD,
and to elucidate underlying mechanisms. A triple-transgenic mouse model of AD (3xTgAD
mice) and nontransgenic control mice were used to test for an affect of chronic mild social …
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